In a recent study, researchers found long-term use of two antidepressants is linked to a higher risk of dementia.
In addition, drugs prescribed for bladder conditions and Parkinson’s are also linked to dementia risk.
The research was conducted by researchers from the University of East Anglia.
Currently, more than 50 million people in the world are affected by dementia and this number is estimated to be 132 million by 2050.
Anticholinergic drugs have been used to treat many conditions. They work by blocking a key messenger (neurotransmitter) in the body called acetylcholine.
Previous studies have shown that anticholinergic antidepressants have been found to be linked with dementia, even when taken up to 20 years before a diagnosis.
In the current study, the team examined the medical records of 40,770 patients aged over 65 diagnosed with dementia.
They compared them to the records of 283,933 people without dementia. About 27 million prescriptions were analyzed.
They focused on the connections between different types of anticholinergic medication and dementia diagnosis.
They found patients who were prescribed anticholinergic antidepressants and anticholinergic medication for bladder conditions and Parkinson’s had a higher risk of dementia.
The findings suggest that doctors should consider long-term anti-cholinergic effects when prescribing.
In addition, patients with concerns should consult their doctor or pharmacist.
The study is published in BMJ.
FOR MY READERS, BELOW IS A LIST OF THE DRUGS THAT ARE ANTICHOLINERGIC WITH A LITTLE MORE INFO ABOUT THEM
- Amitriptyline (Elavil)
- Benztropine (Cogentin)
- Chlorpheniramine (Actifed, Allergy & Congestion Relief, Chlor-Trimeton, Codeprex,
- Efidac-24 Chlorpheniramine, etc.)
- Chlorpromazine (Thorazine)
- Clomipramine (Anafranil)
- Clozapine (Clozaril)
- Cyclobenzaprine (Amrix, Fexmid, Flexeril)
- Cyproheptadine (Periactin)
- Desipramine (Norpramin)
- Dicyclomine (Bentyl)
- Diphenhydramine (Advil PM, Aleve PM, Bayer PM, Benadryl, Excedrin PM, Nytol, Simply
- Sleep, Sominex, Tylenol PM, Unisom, etc.)
- Doxepin (Adapin, Silenor, Sinequan)
- Fesoterodine (Toviaz)
- Hydroxyzine (Atarax, Vistaril)
- Hyoscyamine (Anaspaz, Levbid, Levsin, Levsinex, NuLev)
- Imipramine (Tofranil)
- Meclizine (Antivert, Bonine)
- Nortriptyline (Pamelor)
- Olanzapine (Zyprexa)
- Orphenadrine (Norflex)
- Oxybutynin (Ditropan, Oxytrol)
- Paroxetine (Brisdelle, Paxil)
- Perphenazine (Trilafon)
- Prochlorperazine (Compazine)
- Promethazine (Phenergan)
- Protriptyline (Vivactil)
- Pseudoephedrine HCl/Triprolidine HCl (Aprodine)
- Scopolamine (Transderm Scop)
- Thioridazine (Mellaril)
- Tolterodine (Detrol)
- Trifluoperazine (Stelazine)
- Trimipramine (Surmontil)
OTHER ANTICHOINERGIC DRUGS (WITH SLIGHTLY LESS AC EFFECT)
- Alprazolam (Xanax)
- Amantadine (Symmetrel)
- Carisoprodol (Soma)
- Cetirizine (Zyrtec)
- Cimetidine (Tagamet)
- Clorazepate (Tranxene)
- Digoxin (Lanoxicaps, Lanoxin)
- Diphenoxylate (Lomotil)
- Fluphenazine (Prolixin)
- Furosemide (Lasix)
- Hydrochlorothiazide (Esidrix, Dyazide, HydroDIURIL, Maxzide & literally scores of other medications for high blood pressure)
- Loperamide (Imodium)
- Loratadine (Alavert, Claritin)
- Nifedipine (Adalat, Procardia)
- Ranitidine (Zantac)
- Thiothixene (Navane)
- Tizanidine (Zanaflex)
Why are Anticholinergic drugs used?
Drugs with anticholinergic properties have been used in medicine for decades to treat conditions such as:
- Overactive bladder and urinary incontinence
- Chronic obstructive pulmonary disease (COPD)
- Surgery and anesthesia for muscle relaxation
- Motion sickness
- Toxicity of certain poisonings
- Parkinson’s disease symptoms
- Psychiatric disorders
- Gastrointestinal disorders
- Some symptoms of Parkinson’s disease
- Anesthesia during surgery
What are the signs of a possible overdose?
- Severe drowsiness
- Severe hallucinations
- Trouble breathing
- Clumsiness and slurred speech
- Fast heartbeat
- Flushing and warmth of the skin